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DSG1 Polyclonal antibody, PBS Only (24587-1-PBS)

Filter: AllIHCIF/ICC

IHC staining of human skin cancer using 24587-1-AP (same clone as 24587-1-PBS)
Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 24587-1-AP (DSG1 antibody) at dilution of 1:400 (under 10x lens). heat mediated antigen retrieval with Tris-EDTA buffer(pH9). This data was developed using the same antibody clone with 24587-1-PBS in a different storage buffer formulation.
IHC staining of human skin cancer using 24587-1-AP (same clone as 24587-1-PBS)
Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 24587-1-AP (DSG1 antibody) at dilution of 1:400 (under 40x lens). heat mediated antigen retrieval with Tris-EDTA buffer(pH9). This data was developed using the same antibody clone with 24587-1-PBS in a different storage buffer formulation.
IHC staining of mouse skin using 24587-1-AP (same clone as 24587-1-PBS)
Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 24587-1-AP (DSG1 antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24587-1-PBS in a different storage buffer formulation.
IHC staining of mouse skin using 24587-1-AP (same clone as 24587-1-PBS)
Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 24587-1-AP (DSG1 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24587-1-PBS in a different storage buffer formulation.
IHC staining of rat skin using 24587-1-AP (same clone as 24587-1-PBS)
Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using 24587-1-AP (DSG1 antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24587-1-PBS in a different storage buffer formulation.
IHC staining of rat skin using 24587-1-AP (same clone as 24587-1-PBS)
Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using 24587-1-AP (DSG1 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24587-1-PBS in a different storage buffer formulation.
IF Staining of A431 using 24587-1-AP (same clone as 24587-1-PBS)
Immunofluorescent analysis of (-20°C Methanol) fixed A431 cells using DSG1 antibody (24587-1-AP) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 24587-1-PBS in a different storage buffer formulation.

DSG1 Polyclonal antibody, PBS Only

Name: DSG1 Polyclonal antibody, PBS Only
Brand: Proteintech
SKU: 24587-1-PBS

DSG1 Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA

Cat No. 24587-1-PBS

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, IF/ICC, Indirect ELISA

Synonyms

Cadherin family member 4, CDHF4, desmoglein 1, Desmoglein-1, Desmosomal glycoprotein 1

Formulation: PBS Only

PBS, Azide, Glycerol

Conjugate: Unconjugated

Size/Concentration:

-/ -

Freight/Packing: -

Quantity

- +

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Overview

Tested Applications
Product Information

Print datasheet

MSDS SDS

Product Information

24587-1-PBS targets DSG1 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity	human, mouse, rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CatNo: Ag20184 Product name: Recombinant human DSG1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 756-1049 aa of BC153001 Sequence: KKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK Predict reactive species
Full Name	desmoglein 1
Calculated Molecular Weight	1049 aa, 114 kDa
GenBank Accession Number	BC153001
Gene Symbol	DSG1
Gene ID (NCBI)	1828
RRID	AB_2879624
Conjugate	Unconjugated
Form	Liquid
Purification Method	Antigen affinity purification
UNIPROT ID	Q02413
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG1 is a single-pass transmembrane glycoprotein highly expressed in the epidermis and localized primarily within the suprabasal epithelial layers (PMID: 16286477; 24220297). DSG1 mediates intercellular adhesion and is crucial in maintaining epidermal integrity and barrier function (PMID: 23974871). It is also involved in epithelial cell differentiation (PMID: 23524961). Mutations in the DSG1 gene can cause the autosomal dominant disorder to striate palmoplantar keratoderma and a syndrome featuring severe dermatitis, multiple allergies, and metabolic wasting (SAM syndrome) (PMID: 29315490; 23974871).