|Positive WB detected in||HUVEC cells|
|Western Blot (WB)||WB : 1:1500-1:6000|
|Sample-dependent, check data in validation data gallery|
66537-1-Ig targets EXOC3L2 in WB,ELISA applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||EXOC3L2 fusion protein Ag26912|
|Full Name||exocyst complex component 3-like 2|
|Calculated molecular weight||46 kDa|
|Observed molecular weight||46 kDa|
|GenBank accession number||BC104947|
|Gene ID (NCBI)||90332|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
The exocyst is a protein complex that ensures spatial targeting of exocytotic vesicles to the plasma membrane. Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells (PMID: 21566143). The gene of human EXOC3L2 maps to chromosome 19q13.32 and encodes a deduced 409-amino acid protein with a calculated molecular mass of about 46 kDa. Mouse Exoc3l2 gene encodes an approximately 250-amino acid protein that lacks the N-terminal domain of human EXOC3L2. Mutations in EXOC3L2 gene may be associated with Alzheimer's disease.