Glutamine synthetase Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 11037-2-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 25 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
rat liver tissue,mouse brain tissue, HepG2 cells, mouse liver tissue

Positive IHC detected in:
human liver cancer tissue

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
glutamate-ammonia ligase (glutamine synthetase)

Calculated molecular weight:
374aa,42 kDa

Observed molecular weight:
44 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GLUL

Synonyms
GLNS, GLUL, Glutamate ammonia ligase, Glutamate decarboxylase, Glutamine synthetase, GS, PIG43, PIG59
Background

GLUL(Glutamine synthetase) is also named as GS,GLNS and belongs to the glutamine synthetase family.This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner By similarity. Essential for proliferation of fetal skin fibroblasts(PMID:18662667).Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD).Organismal glutamine production is augmented secondary to an increase in the activity of glutamine synthetase in the lung and skeletal muscle(PMID:7630137). There are other bands with higher (66 kDa, 97 kDa) and lower (30 kDa)molecular weights also detected besides the 42 kDa band indicating the proteolysis of GLUL protein by the ubiquitin system(PMID:10091759).


Back
to top