GR repeat Polyclonal antibody

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• GR repeat Polyclonal antibody (23978-1-AP)

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GR repeat Polyclonal Antibody for WB, ELISA

Cat No. 23978-1-AP Copied!

Publications (33)

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Host / Isotype

Rabbit / IgG

Reactivity

human and More (3)

Applications

WB, IHC, IF, Dot Blot, ELISA

Synonyms

C9RAN, GGGCC, GRGRGRGRG, GRGRGRGRGR, Poly-GR

• 

  WB analysis of Recombinant protein using 23978-1-AP

  Recombinant protein were subjected to SDS PAGE followed by western blot with 23978-1-AP (GR repeat Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: Recombinant protein

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

23978-1-AP targets GR repeat in WB, IHC, IF, Dot Blot, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human, mouse, zebrafish, drosophila
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: GR repeat
• RRID: AB_2879387
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

The C9orf72 "GGGGCC" repeat sequence codes five repeat peptide "GA repeat; GAGAGAGAGA", "GP repeat; GPGPGPGPG", "GR repeat; GRGRGRGRG", "AP repeat; APAPAPAPA" and "PR repeat; PRPRPRPRP". It was described previously that aggregated forms of poly-GA and poly-GP proteins do not enter the separation gel (PMID: 26374446). This antibody is used to detect the GR repeated sequence. The recombinant proteins GST-SNRPD1 and 6*His tag- SNRPD1 which contains the sequence "GRGRGRGRGRGRGRGRGR" were used to detect this antibody. Both proteins can be recognized by the antibody 23978-1-AP.

Publications

What published studies show

Anti-C9orf72 (Cat# 23978-1-AP) has 33 citations published in journals including Nature, Science, Cell, Neuron, Nat Commun, Sci Transl Med, Brain, Acta Neuropathol, EMBO J, Cell Rep, Hum Mol Genet, and others. Research fields center on C9orf72 hexanucleotide repeat expansion, ALS/FTD neurodegeneration, dipeptide repeat protein toxicity, stress granule assembly, nucleocytoplasmic transport disruption, and related therapeutic interventions.

Automatically generated from the 33 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
	WB	Nature; The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.; Authors - Ke Zhang
Drosophila	WB	Science; C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.; Authors - Sarah Mizielinska
mouse,human	IF	Cell; PIKFYVE inhibition mitigates disease in models of diverse forms of ALS; Authors - Shu-Ting Hung
human	IF	Cell; Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.; Authors - Ke Zhang ; KD Validated
mouse	IF	Cell Stem Cell; SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS; Authors - Gabriel R Linares
human	IHC	Nat Neurosci; RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats.; Authors - Shizuka B Yamada