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Recombinant Human Complement C2 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3058

Validation Data Gallery

  • Purity of Recombinant Human Complement C2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Complement C2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human Complement C2 protein Ala21-Leu752 (Accession# P06681-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 717
Accession P06681-1
PredictedSize 107.1 kDa
SDS-PAGE 90-125 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Complement C2 is one of the serum glycoproteins in the classical and MBL pathways of complement activation. C2 is made up of three globular domains. The N-terminal domain, which constitutes the C2b segment, is made up of three short consensus repeats (SCRs). C2 deficiency carries an increased risk of developing systemic lupus erythematosus, recurrent infections and atherosclerosis.

References:

1. Tange CE, et al. (2018). Clin Chem Lab Med. Aug 28;56(9):1498-1506.
2. Huda R, et al. (2013). J Autoimmun. May;42:94-104. 
3. Budding K, , et al. (2021). Neurol Neuroimmunol Neuroinflamm. Nov 10;9(1):e1107. 
4. Laich A, et al. (2022). Immunobiology. May;227(3):152225.