Recombinant Human Cadherin-13 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg5964
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human Cadherin-13 protein Ser139-Gly693 (Accession# P55290-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 1012 |
| Accession | P55290-1 |
| PredictedSize | 86.4 kDa |
| SDS-PAGE | 90-115 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Cadherin-13 (CDH13, also known as H-cadherin or T-cadherin) is an atypical member of cadherin family, lacking transmembrane and cytosolic domains and anchored to the exterior surface of the plasma membrane via a GPI anchor. CDH13 is thought to affect cellular behavior largely through its signaling properties. It is highly expressed in heart, and in the CNS, CDH13 is expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. It is often down-regulated in cancerous cells.
References:
1. Philippova, Maria et al. Cellular signalling vol. 21,7 (2009): 1035-44. 2. Paredes, Joana et al. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 11,16 (2005): 5869-77. 3. Xu, Yidong et al. Experimental and therapeutic medicine vol. 18,1 (2019): 841-847.