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Cytokeratin 17-Specific Polyclonal antibody
Cytokeratin 17-Specific Polyclonal Antibody for FC, IF, IHC, IP, WB, ELISA
Cat no : 17516-1-AP
|Positive WB detected in||A431 cells, HEK-293 cells, HeLa cells, mouse skin tissue|
|Positive IP detected in||A431 cells|
|Positive IHC detected in||human cervical cancer tissue, human lung cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HeLa cells|
|Positive FC detected in||HeLa cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
17516-1-AP targets Cytokeratin 17-Specific in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Full Name||keratin 17|
|Calculated molecular weight||48 kDa|
|Observed molecular weight||48 kDa|
|GenBank accession number||NM_000422|
|Gene ID (NCBI)||3872|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9-K23, and the hair keratins Ha1-Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1-K8, and the hair keratins, Hb1-Hb6. Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. It is used as a marker for trauma. This antibody is specifically against KRT17.
|Product Specific Protocols|
|WB protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|IHC protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|IF protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|IP protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|FC protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Cytokeratin expression in epidermal stem cells in skin adnexal tumors.
Cancer Manag Res
Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis.
Breast Cancer Res
Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation.
Keratin17 Promotes Tumor Growth and is Associated with Poor Prognosis in Gastric Cancer.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Clin Cancer Res
A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer.