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Cytokeratin 17-Specific Polyclonal antibody
Cytokeratin 17-Specific Polyclonal Antibody for FC, IF, IHC, IP, WB,ELISA
Cat no : 17516-1-AP
|Positive WB detected in||A431 cells, HEK-293 cells, HeLa cells, mouse skin tissue|
|Positive IP detected in||A431 cells|
|Positive IHC detected in||human cervical cancer tissue, human lung cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HeLa cells|
|Positive FC detected in||HeLa cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
17516-1-AP targets Cytokeratin 17-Specific in WB, IP, IHC, IF, FC,ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Full Name||keratin 17|
|Calculated molecular weight||48 kDa|
|Observed molecular weight||48 kDa|
|GenBank accession number||NM_000422|
|Gene ID (NCBI)||3872|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9-K23, and the hair keratins Ha1-Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1-K8, and the hair keratins, Hb1-Hb6. Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. It is used as a marker for trauma. This antibody is specifically against KRT17.
|Product Specific Protocols|
|WB protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|IHC protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|IF protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|IP protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|FC protocol for Cytokeratin 17-Specific antibody 17516-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Cytokeratin expression in epidermal stem cells in skin adnexal tumors.
Cancer Manag Res
Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis.
Breast Cancer Res
Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation.
Keratin17 Promotes Tumor Growth and is Associated with Poor Prognosis in Gastric Cancer.
Onco Targets Ther
Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.