METTL3 Antibody 14 Publications

Rabbit Polyclonal| Catalog number: 15073-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HepG2 cells, HeLa cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human lung cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
methyltransferase like 3

Calculated molecular weight:
64 kDa

Observed molecular weight:
65-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
METTL3

Synonyms
IME4, M6A, methyltransferase like 3, METTL3, MT A70, MTA70, Spo8
Background

METTL3 is a key S-adenosyl-L-methionine-binding subunit, which is component of a complex multicomponent enzyme that catalyzes the methylation of internal adenosine residues in eukaryotic mRNA, forming N6-methyladenosine. It contains 2 putative nuclear localization signals and 2 consensus methylation motifs. The calculated molecular weight of METTL3 is 64 kDa, but modified METTL3 is about 65-70 kDa.


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