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- KD/KO Validated
CoraLite® Plus 488-conjugated METTL3 Monoclonal antibody
METTL3 Monoclonal Antibody for
Host / Isotype
Mouse / IgG1
Reactivity
Human, mouse
Applications
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
2D8H1
Cat no : CL488-67733
Synonyms
Validation Data Gallery
Product Information
CL488-67733 targets METTL3 in applications and shows reactivity with Human, mouse samples.
| Tested Reactivity | Human, mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | METTL3 fusion protein Ag7110 |
| Full Name | methyltransferase like 3 |
| Calculated Molecular Weight | 64 kDa |
| Observed Molecular Weight | 70 kDa |
| GenBank Accession Number | BC001650 |
| Gene Symbol | METTL3 |
| Gene ID (NCBI) | 56339 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
METTL3 is a key S-adenosyl-L-methionine-binding subunit, which is component of a complex multicomponent enzyme that catalyzes the methylation of internal adenosine residues in eukaryotic mRNA, forming N6-methyladenosine. It contains 2 putative nuclear localization signals and 2 consensus methylation motifs. The calculated molecular weight of METTL3 is 64 kDa, but modified METTL3 is about 65-70 kDa.
