CoraLite®647-conjugated Noggin Monoclonal antibody

Noggin Monoclonal Antibody for FC

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

FC

Conjugate

CoraLite®647 Fluorescent Dye

CloneNo.

2A11C1

Cat no : CL647-69010

Synonyms

NOG, noggin, SYM1, SYNS1



Tested Applications

Positive FC detected inPC-3 cells
For other applications, we recommend the unconjugated version of this antibody, 69010-1-Ig

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

CL647-69010 targets Noggin in FC applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen Noggin fusion protein HZ-1118
Full Name noggin
Gene symbol NOG
Gene ID (NCBI) 9241
Conjugate CoraLite®647 Fluorescent Dye
Excitation/Emission maxima wavelengths650 nm/665 nm
Form Liquid
Purification Method Protein G purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

Background Information

Noggin is an extracellular polypeptide acting as an antagonist of bone morphogenetic proteins (BMPs) regulating embryonal development. Noggin inhibits activity of BMP-2, -4, -7, -13, and -14. Noggin is present extracellularly in the matrix or retained at the cell surface via interaction with heparin sulfate proteoglycans. In early development stages, Noggin is produced by the Spemann organizer, allowing dorsal-ventral patterning of BMPs (PMID: 8752214). Subsequently, Noggin is expressed by the notochord regulating BMP-4 signaling in neurogenesis. Additionally, Noggin is present during development in the dermal papilla, connective tissue of the hair follicle, lens, retina, and periocular mesenchyme, as well as in the mesoderm lineage regulating development of the bone, cartilage, and muscles.

This antibody is used to Block/Neutralize Noggin protein.

Protocols

Product Specific Protocols
FC protocol for CL647 Noggin antibody CL647-69010Download protocol
Standard Protocols
Click here to view our Standard Protocols