NeutraKine® Noggin Monoclonal antibody

NeutraKine® Noggin Monoclonal Antibody for FC, Neutralization,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Neutralization, FC,ELISA

Conjugate

Unconjugated

CloneNo.

2A11C1

Cat no : 69010-1-Ig

Synonyms

NOG, noggin, SYM1, SYNS1



Tested Applications

Planning an IF experiment? We recommend our CoraLite®488 and CoraLite®647 conjugated versions of this antibody.
Neutralization

Product Information

69010-1-Ig targets NeutraKine® Noggin in Neutralization, FC,ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen human NeutraKine® Noggin protein HZ-1118
Full Name noggin
Gene symbol NOG
Gene ID (NCBI) 9241
Conjugate Unconjugated
Form Lyophilized Powder
Purification Method Protein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

Noggin is an extracellular polypeptide acting as an antagonist of bone morphogenetic proteins (BMPs) regulating embryonal development. Noggin inhibits activity of BMP-2, -4, -7, -13, and -14. Noggin is present extracellularly in the matrix or retained at the cell surface via interaction with heparin sulfate proteoglycans. In early development stages, Noggin is produced by the Spemann organizer, allowing dorsal-ventral patterning of BMPs (PMID: 8752214). Subsequently, Noggin is expressed by the notochord regulating BMP-4 signaling in neurogenesis. Additionally, Noggin is present during development in the dermal papilla, connective tissue of the hair follicle, lens, retina, and periocular mesenchyme, as well as in the mesoderm lineage regulating development of the bone, cartilage, and muscles.

This antibody is used to Block/Neutralize Noggin protein.

Protocols

Product Specific Protocols
Neutralization protocol of NeutraKine® Noggin antibody 69010-1-IgDownload protocol
FC protocol for NeutraKine® Noggin antibody 69010-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols