Phospho-ITPR1 (Ser1764) Recombinant monoclonal antibody, PBS Only

• 

  WB analysis of mouse brain using 87294-1-RR (same clone as 87294-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 87294-1-RR (Phospho-ITPR1 (Ser1764) antibody) blocked with BSA only, Phospho-ITPR1 (Ser1764) peptide or non-Phospho peptide at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87294-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat brain using 87294-1-RR (same clone as 87294-1-PBS)

  rat brain tissue were subjected to SDS PAGE followed by western blot with 87294-1-RR (Phospho-ITPR1 (Ser1764) antibody) blocked with BSA only, Phospho-ITPR1 (Ser1764) peptide or non-Phospho peptide at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87294-1-PBS in a different storage buffer formulation.

Phospho-ITPR1 (Ser1764) Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 87294-1-PBS

Clone No.252582D10

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

Phospho IP3 Receptor (Ser1756), Phospho-IP3 Receptor, Phospho-IP3 Receptor (Ser1756), Phospho-ITPR1, Phospho-ITPR1-Ser1764

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Product Information

87294-1-PBS targets Phospho-ITPR1 (Ser1764) in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: inositol 1,4,5-triphosphate receptor, type 1
• Calculated Molecular Weight: 314 kDa
• Observed Molecular Weight: 320 kDa
• GenBank Accession Number: NM_001378452
• Gene Symbol: ITPR1
• Gene ID (NCBI): 3708
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q14643
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ITPR1, also named as INSP3R1 and IP3R, belongs to the InsP3 receptor family. Phospho-ITPR1 (Thr853) is a phosphorylated form of the inositol-trisphosphate receptor type 1 (ITPR1) protein at threonine residue 853. This phosphorylation site is involved in the regulation of calcium signaling pathways within cells. The specific function and role of Thr853 phosphorylation in ITPR1's activity are not detailed in the provided resources, but phosphorylation events on ITPR1 are known to influence its function, which affects calcium release from the endoplasmic reticulum. Calcium signaling is critical for various cellular processes, including muscle contraction, neurotransmitter release, and cellular division. This antibody is equivalent to Ser1756 in rat.