Phospho-LYN (Tyr508) Recombinant monoclonal antibody, PBS Only

• 

  WB analysis using 86947-2-RR (same clone as 86947-2-PBS)

  Ramos cell lysates were subjected to SDS PAGE followed by western blot with 80351-3-RR (Phospho-LYN (Tyr508)antibody) blocked with BSA only, Phospho-LYN (Tyr508) peptide or non-Phospho peptide at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86947-2-PBS in a different storage buffer formulation.

Phospho-LYN (Tyr508) Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 86947-2-PBS

Clone No.251104F11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

LYN, EC:2.7.10.2, JTK8, Lck/Yes-related novel protein tyrosine kinase, Tyrosine protein kinase Lyn

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Product Information

86947-2-PBS targets Phospho-LYN (Tyr508) in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
• Calculated Molecular Weight: 512 aa, 59 kDa
• Observed Molecular Weight: 53 kDa, 56 kDa
• GenBank Accession Number: BC075002
• Gene Symbol: LYN
• Gene ID (NCBI): 4067
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P07948
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

LYN, also named as JTK8, p53Lyn and p56Lyn, belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. The C-terminal tyrosine-508 residue (Tyr-508) in Lyn or the corresponding conserved tyrosine residue in each of the other members of the SFK family is the primary site for regulating tyrosine kinase activity by reversible phosphorylation. Phosphorylation at the tyrosine residue induces a closed conformation that is enzymatically inactive. (PMID: 33004926)