Product Information
18172-1-PBS targets RNASE2/EDN in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag12834 Product name: Recombinant human RNASE2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 31-161 aa of BC093678 Sequence: QFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII Predict reactive species |
| Full Name | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) |
| Calculated Molecular Weight | 161 aa, 18 kDa |
| Observed Molecular Weight | 18 kDa |
| GenBank Accession Number | BC093678 |
| Gene Symbol | RNASE2 |
| Gene ID (NCBI) | 6036 |
| RRID | AB_3669293 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P10153 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
RNASE2, also known as eosinophil-derived neurotoxin (EDN), is a member of the RNase A superfamily and is predominantly expressed in eosinophilic leukocytes, where it is stored in large quantities within specific cytoplasmic granules. Structurally, RNASE2 possesses a catalytic domain that confers ribonuclease activity, which enables its primary role in the host immune response against viral infections by directly degrading viral RNA, thereby inhibiting viral replication. Upon release from activated eosinophils, RNASE2 can signal through pattern recognition receptors such as Toll-like receptor 2 (TLR2) to activate dendritic cells and promote T-helper type 2 (Th2) immune responses. Elevated levels of RNASE2 are found in various inflammatory conditions, including asthma, allergic rhinitis, and parasitic infections, making it a key biomarker for eosinophil activation. Beyond its roles in immunity and inflammation, RNASE2 also exhibits neurotoxic activity, and has been implicated in wound healing and tissue remodeling processes.
