SUR1 Polyclonal antibody, PBS Only

• 

  WB analysis using 55172-1-AP (same clone as 55172-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 55172-1-AP (SUR1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55172-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 55172-1-AP (same clone as 55172-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 55172-1-AP (SUR1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55172-1-PBS in a different storage buffer formulation.

SUR1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 55172-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

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Product Information

55172-1-PBS targets SUR1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
• Calculated Molecular Weight: 177 kDa
• Observed Molecular Weight: 140–177 kDa
• GenBank Accession Number: NM_000352
• Gene Symbol: SUR1
• Gene ID (NCBI): 6833
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q09428
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SUR1 (Sulfonylurea receptor 1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, which encompasses a large group of membrane proteins that regulate the transport of ions and molecules across lipid bilayers (PMID:34769328). SUR1 regulates ATP-sensitive K+ channels and insulin release. Loss-of-function SUR1 mutations cause congenital hyperinsulinism and gain-of-function SUR1 mutations leading to neonatal diabetes (PMID: 18990670). SUR1 is recognized as a key mediator of central nervous system cellular swelling by the transient receptor potential melastatin 4 (TRPM4) channel. SUR1 (Sulfonylurea receptor 1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, which encompasses a large group of membrane proteins that regulate the transport of ions and molecules across lipid bilayers (PMID:34769328). SUR1 regulates ATP-sensitive K+ channels and insulin release. Loss-of-function SUR1 mutations cause congenital hyperinsulinism and gain-of-function SUR1 mutations leading to neonatal diabetes (PMID: 18990670). SUR1 is recognized as a key mediator of central nervous system cellular swelling by the transient receptor potential melastatin 4 (TRPM4) channel. SUR1 was detected 140-177 kDa in the pancreas, brain, heart (PMID: 34380876).