Anti-Mouse Tie-2/CD202b Rabbit Recombinant Antibody, PBS Only

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  FC experiment of bEnd.3 using 98219-1-RR (same clone as 98219-1-PBS)

  1x10^6 bEnd.3 cells were surface stained with 0.25 ug Anti-Mouse Tie-2 Rabbit Recombinant Antibody (98219-1-RR, Clone:241753F12) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98219-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98219-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98219-1-RR against Mouse Tie-2/CD202b were performed. The affinity constant is below 1 pM.

Tie-2/CD202b Uni-rAb^® Recombinant Antibody for FC

Cat No. 98219-1-PBS

Clone No.241753F12

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

241753F12, Angiopoietin-1 receptor, CD202b, EC:2.7.10.1, Endothelial tyrosine kinase

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Product Information

98219-1-PBS targets Tie-2/CD202b in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg1514

  Product name: Recombinant Mouse Tie-2/CD202b protein (rFc Tag)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 23-744 aa of NM_001290549.1

  Sequence: AMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCSRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGPEGCKSYVFCLPDPYGCSCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDRFQGCLCSQGWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTVLQPNDFNYTDRFSVAIFTVNRVLPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIEVTNEIFTLNYLEPRTDYELCVQLARPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTNSEDEFYVEVERRSLQTTSDQQNIKVPGNLTSVLLSNLVPREQYTVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKISNITDSTAMVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATVTQYQLKGLEPETTYHVDIFAENNIGSSNPAFSHELRTLPHSPASADLGGGK

• Full Name: endothelial-specific receptor tyrosine kinase
• Calculated Molecular Weight: 126 kDa
• GenBank Accession Number: NM_001290549.1
• Gene Symbol: Tek
• Gene ID (NCBI): 21687
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q02858
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Tie-2, also known as CD202b or TEK, is a receptor tyrosine kinase (RTK) specifically expressed in endothelial cells. It plays a crucial role in angiogenesis, forming new blood vessels, and maintaining vascular stability. Tie-2 is a member of the Tie receptor family, characterized by the presence of immunoglobulin and epidermal growth factor (EGF) homology domains. Tie-2 plays a significant role in several vascular diseases, including vascular malformations like venous malformations. It is also implicated in pathological vascular remodeling associated with tumor growth, where it is often overexpressed in tumor vessels.