VEGF Antibody 80 Publications

Rabbit Polyclonal| Catalog number: 19003-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 55 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
PC-3 cells, A431 cells, HepG2 cells, Jurkat cells, MCF-7 cells, NIH/3T3 cells

Positive IP detected in:
MCF-7 cells

Positive IHC detected in:
human lung cancer tissue,human placenta tissue, human liver cancer tissue, human kidney tissue, human colon cancer tissue, human oesophagus tissue

Positive IF detected in:
HeLa cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vascular endothelial growth factor A

Calculated molecular weight:
412aa,46 kDa

Observed molecular weight:
23-27 kDa,45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VEGFA

Synonyms
L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGFA, VPF
Background

VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010 ). This antibody can recognize all the isoforms of VEFGA.


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