CD154 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 16668-1-AP

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Freight/Packing

Con: 45 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse small intestine tissue, HeLa cells, Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human spleen tissue, human heart tissue, human kidney tissue, human liver tissue, human lung tissue, human ovary tissue, human spleen tissue, human testis tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD40 ligand

Calculated molecular weight:
261aa,29 kDa

Observed molecular weight:
29-32 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD40LG

Synonyms
CD154, CD40 L, CD40 ligand, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T BAM, T cell antigen Gp39, TNF related activation protein, TNFSF5, TRAP
Background

The CD40 ligand (CD40L, TRAP, CD154), a member of the TNF superfamily of ligands, is expressed as either a 33-kd transmembrane homologue or 18-kd soluble form (sCD154). CD40L is primarily expressed on activated CD4+ T cells and on a small proportion of CD8+ T cells and platelets. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. Recent studies have suggested that CD40/CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and the cardiovascular systems. The CD40/CD40L system is also involved in tumorigenesis.


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