HRPT2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12310-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human lung tissue, human heart tissue, mouse testis tissue

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Calculated molecular weight:
531aa,61 kDa

Observed molecular weight:
61 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDC73

Synonyms
C1orf28, CDC73, FLJ23316, HPT JT, HRPT2, Hyperparathyroidism 2 protein, Parafibromin
Background

Parafibromin is a product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2/CDC73, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome, sporadic parathyroid cancer, and a minority of families with isolated hyperparathyroidism (PMID: 15580289). Defects in CDC73 are causes of hyperparathyroidism type 1 (HRPT1) and hyperparathyroidism type 2 (HRPT2) as well as parathyroid carcinoma (PRTC) (PMID: 12434154). Tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein (PMID: 15923622). Besides, parafibromin is also involved in post-transcriptional control pathways (PMID: 16116486). Recent report has revealed that pathogenic mutation, such as CDC73 gene mutation, is able to affect histone monoubiquitination (PMID: 22021426).


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