Alpha E catenin Antibody 1 Publications

Mouse Monoclonal| Catalog number: 66221-1-Ig |CloneNo.: 2B7B8

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Freight/Packing

Con: 312 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
NIH/3T3 cells

Positive IHC detected in:
human stomach tissue, human colon tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:1000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
catenin (cadherin-associated protein), alpha 1, 102kDa

Calculated molecular weight:
906aa,100 kDa

Observed molecular weight:
95-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTNNA1

Synonyms
Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1
Background

Alpha catenin is an essential component of adherens junctions that connects E-cadherin-β-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin, alpha-N-catenin, and alpha-T-catenin, which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed, alpha-N-catenin is restricted to neuronal tissue, and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers, including malignant tumours of the breast, colon, stomach, oesophagus, bladder and liver. In addition, the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis.


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