beta-Catenin Antibody 2 Publications

Mouse Monoclonal| Catalog number: 66379-1-Ig |CloneNo.: 1B8A1

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Freight/Packing

Con: 150 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
MCF-7 cells, pig brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human liver cancer tissue, human breast cancer tissue, human liver cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:2000-1:12000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:100-1:1000
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
catenin (cadherin-associated protein), beta 1, 88kDa

Calculated molecular weight:
781aa,86 kDa

Observed molecular weight:
92 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTNNB1

Synonyms
b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, PRO2286
Background

β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin was originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)


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