CXCL12 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 17402-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse

Positive IHC detected in:
human liver cancer tissue, human liver cancer tissue, human tonsillitis tissue

Recommended dilution:
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

Calculated molecular weight:
89aa,10 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CXCL12

Synonyms
C X C motif chemokine 12, CXCL12, hIRH, hSDF 1, IRH, PBSF, SCYB12, SDF 1, SDF 1a, SDF 1b, SDF1, SDF1A, SDF1B, Stromal cell derived factor 1, TLSF a, TLSF b, TPAR1
Background

In adulthood, CXCL12 plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPCs) from the bone marrow through a CXCR4 dependent mechanism (PMID: 17878755). It is this function of CXCL12 that makes it a very important factor in carcinogenesis and the neovascularisation linked to tumour progression (PMID: 16943240). CXCL12 also has a role in tumor metastasis where cancer cells that express the receptor CXCR4 are attracted to metastasis target tissues that release the ligand, CXCL12 (PMID: 11242036 ). In breast cancer, however, increased expression of CXCL12 determines a reduced risk of distant metastasis (PMID: 19646861; 17724466 ).


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