DNMT1 Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 24206-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 61 μg/150 μl

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Species specificity:
human, rat, chicken, pig

Positive WB detected in:
HEK-293 cells, Transfected HEK-293 cells

Positive IP detected in:
HEK-293 cells

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
DNA (cytosine-5-)-methyltransferase 1

Calculated molecular weight:
1632aa,185 kDa

Observed molecular weight:
180-200 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DNMT1

Synonyms
AIM, CXXC9, DNA MTase HsaI, DNMT, DNMT1, MCMT
Background

DNA methylation is a major epigenetic modification that regulates gene expression. DNMT1, the maintenance DNA methylation enzyme, is the primary enzyme responsible for copying methylation patterns after DNA replication. DNMT1 is required for X chromosome inactivation, imprinting, genomic methylation and proper embryonic development. Overexpression of DNMT1 has been reported in various cancers. DNMT1 exists some isoforms with MV 184 kDa and 145 kDa. (PMID: 10753866)


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