IBA1 Antibody 53 Publications

Rabbit Polyclonal| Catalog number: 10904-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 47 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat, hamsters

Positive WB detected in:
mouse spleen tissue, rat spleen tissue

Positive IP detected in:
U-937 cells

Positive IHC detected in:
mouse brain tissue,human brain tissue, human liver tissue, human lymphoma tissue, human tonsillitis tissue

Positive IF detected in:
human gliomas tissue,HepG2 cells, C6 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
allograft inflammatory factor 1

Calculated molecular weight:
17 kDa

Observed molecular weight:
17 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AIF1

Synonyms
AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1
Background

AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.


Back
to top