NAMPT/PBEF Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 11776-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
mouse skeletal muscle tissue, HL-60 cells, mouse heart tissue, mouse liver tissue, Ramos cells, rat liver tissue, RAW 264.7 cells, zebrafish tissue

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
human ovary tumor tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nicotinamide phosphoribosyltransferase

Calculated molecular weight:
52 kDa

Observed molecular weight:
56 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NAMPT

Synonyms
1110035O14Rik, DKFZp666B131, NAmPRTase, NAMPT, PBEF, PBEF1, Pre B cell enhancing factor, VF, VISFATIN
Background

Nicotinamide phosphoribosyltransferase(NAMPT) has two usual synonyms termed Visfatin and PBEF. Its primary role is to catalyze the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD, which is the rate limiting component in the mammalian NAD biosynthesis pathway. NAMPT is localized in cytoplasm and expressed in large amounts in bone marrow, liver tissue, and muscle tissues. NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. NAMPT levels are altered in plasma of patients with type 2 diabetes mellitus (T2DM), and it is now evidenced that NAMPT may plays a role in lipid metabolism.


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