GHRL Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 13309-1-AP

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, rat, mouse

Positive WB detected in:
human stomach tissue

Positive IHC detected in:
human stomach tissue, human stomach tissue, mouse stomach tissue, rat stomach tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ghrelin/obestatin prepropeptide

Calculated molecular weight:
117aa,13 kDa

Observed molecular weight:
13 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GHRL

Synonyms
Appetite regulating hormone, Ghrelin Obestatin, GHRL, Growth hormone secretagogue, Motilin related peptide, MTLRP, obestatin, Protein M46
Background

GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is predominantly produced in endocrine cells in the gastric mucosa, called X/A-like or ghrelin cells, from where it is secreted into the plasma. In the pituitary gland, ghrelin stimulates growth hormone release and regulates food intake and energy metabolism. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes.


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