PER2 Monoclonal antibody

PER2 Monoclonal Antibody for WB,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, rat and More (1)

Applications

WB,ELISA

Conjugate

Unconjugated

CloneNo.

2E6C3

Cat no : 67513-1-Ig

Synonyms

FASPS, hPER2, KIAA0347, PER2, period homolog 2 (Drosophila)



Tested Applications

Positive WB detected inHEK-293 cells, Y79 cells, BxPC-3 cells, L02 cells, K-562 cells, HL-60 cells, THP-1 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
Sample-dependent, check data in validation data gallery

Published Applications

WBSee 2 publications below

Product Information

67513-1-Ig targets PER2 in WB,ELISA applications and shows reactivity with Human, rat samples.

Tested Reactivity Human, rat
Cited Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen PER2 fusion protein Ag29489
Full Name period homolog 2 (Drosophila)
Calculated molecular weight 137 kDa
Observed molecular weight 136 kDa
GenBank accession numberNM_022817
Gene symbol PER2
Gene ID (NCBI) 8864
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Aliquoting is unnecessary for -20oC storage.

Background Information

PER2, also named as KIAA0347, is a component of the circadian clock mechanism which is essential for generating circadian rhythms. PER2 is a negative element in the circadian transcriptional loop. PER2 influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. It negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) which is characterized by very early sleep onset and offset.

Protocols

Product Specific Protocols
WB protocol for PER2 antibody 67513-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

J Immunol Res

Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.

Authors - Xiyan Tan
humanWB

Cancer Manag Res

Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.

Authors - Zhaoxia Wang