|Positive WB detected in||HEK-293 cells, Y79 cells, BxPC-3 cells, L02 cells, K-562 cells, HL-60 cells, THP-1 cells|
|Western Blot (WB)||WB : 1:5000-1:50000|
|Sample-dependent, check data in validation data gallery|
67513-1-Ig targets PER2 in WB,ELISA applications and shows reactivity with Human, rat samples.
|Tested Reactivity||Human, rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||PER2 fusion protein Ag29489|
|Full Name||period homolog 2 (Drosophila)|
|Calculated molecular weight||137 kDa|
|Observed molecular weight||136 kDa|
|GenBank accession number||NM_022817|
|Gene ID (NCBI)||8864|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Aliquoting is unnecessary for -20oC storage.|
PER2, also named as KIAA0347, is a component of the circadian clock mechanism which is essential for generating circadian rhythms. PER2 is a negative element in the circadian transcriptional loop. PER2 influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. It negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) which is characterized by very early sleep onset and offset.
J Immunol Res
Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.
Cancer Manag Res
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.