|Positive WB detected in||human placenta tissue, mouse placenta tissue|
|Positive IHC detected in||human liver tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HepG2 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
16910-1-AP targets PROS1 in WB, IHC, IF, FC,ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse, Plasmodium falciparum|
|Host / Isotype||Rabbit / IgG|
|Immunogen||PROS1 fusion protein Ag10539|
|Full Name||protein S (alpha)|
|Calculated molecular weight||75 kDa|
|Observed molecular weight||70 kDa|
|GenBank accession number||BC015801|
|Gene ID (NCBI)||5627|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
PROS1, also named as Vitamin K-dependent protein S, is a 676 amino acid protein, which contains 4 EGF-like domains, contains one Gla (gamma-carboxy-glutamate) domain and contains 2 laminin G-like domains. PROS1 as a secreted protein platelets alpha granules is expressed in plasma. PROS1 is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa and helps to prevent coagulation and stimulating fibrinolysis.
Mol Med Rep
Hereditary protein S deficiency leads to ischemic stroke.
The malaria parasite Plasmodium falciparum in red blood cells selectively takes up serum proteins that affect host pathogenicity.
Am J Physiol Heart Circ Physiol
Upregulation of anticoagulant proteins, protein S and tissue factor pathway inhibitor, in the mouse myocardium with cardio-specific TNF-α overexpression.
Am J Hematol
Molecular basis of protein S deficiency in China.
Front Cell Neurosci
Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions.
Mol Cell Proteomics
Multisample Mass Spectrometry-Based Approach for Discovering Injury Markers in Chronic Kidney Disease.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Hongxue (Verified Customer) (01-25-2021)
Nice band for WB