VPS11 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 19140-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 25 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, HEK-293 cells, human heart tissue, human kidney tissue, mouse brain tissue, mouse pancreas tissue

Positive IP detected in:
HEK-293 cells

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vacuolar protein sorting 11 homolog (S. cerevisiae)

Calculated molecular weight:
108 kDa

Observed molecular weight:
108-112 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VPS11

Synonyms
END1, hVPS11, PEP5, RING finger protein 108, RNF108, VPS11
Background

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. In yeast, Vps proteins are involved in the trafficking of endocytic and biosynthetic proteins to the vacuole, which functionally resembles the lysosome of higher organisms. VPS11 is the human homolog of the yeast class C Vps11 protein, a subunit of HOPS (homotypic fusion and protein transport) complex. Mammalian Vps11 may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.


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