You've been automatically redirected here from Humanzyme.com, which is now part of Proteintech Group. Click here to dismiss this alert.
  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human PDGFaa

Activity

Typically ≤ 10 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1215

Synonyms

PDGF 1, PDGF A, PDGF subunit A, PDGF1, PDGFA, PDGFaa



Technical Specifications

GeneID 5154
Species human
Expression HEK293
Activity Typically ≤ 10 ng/mL EC50
Purity >95%
Molecular Mass 35, 40 and 45 kDa, homodimer, glycosylated
Formulation 10 mM HOAc, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 10 mM HOAc containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human PDGFaa is expressed in human 293 cells as a mixture of pro-dimers, pro-mature and mature dimers with an apparent molecular mass of 35 to 45 kDa. The cytokine is produced in a human cell expression system with serum free, chemically defined media.

Background

PDGFaa is a member of the platelet-derived growth factor family. Four members of this family are mitogenic factors for cells of mesenchymal origin, and they are characterized by a motif of eight cysteines. PDGFaa plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, and chemotaxis. It is also required for a normal lung alveolar septum formation during embryogenesis, development of the gastrointestinal tract, and spermatogenesis. PDGFaa is also involved in oligodendrocyte development and l myelination process in the spinal cord and cerebellum PMID: 29408302; 29282077; 27002148).

Synonyms

PDGF 1, PDGF A, PDGF subunit A, PDGF1, PDGFA, PDGFaa

Publications

SpeciesTitle
human

Oxid Med Cell Longev

Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.

Authors - Wenqing Bu
mouse

Stem Cell Reports

Conversion of Fibroblast into Functional Leydig-like Cell Using Defined Small Molecules.

Authors - Yan Yang