GPSM2 Polyklonaler Antikörper

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• KD/KO Validated

GPSM2 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (1)

Anwendung

WB, IHC, IF,ELISA

Konjugation

Unkonjugiert

Publikationen

6

Kat-Nr. : 11608-2-AP

Synonyme

GPSM2, LGN, Mosaic protein LGN, Pins

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Galerie der Validierungsdaten

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 3 publications below
• IHC: See 1 publications below
• IF: See 3 publications below

Produktinformation

11608-2-AP bindet in WB, IHC, IF,ELISA GPSM2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: GPSM2 fusion protein Ag2167
• Vollständiger Name: G-protein signaling modulator 2 (AGS3-like, C. elegans)
• Berechnetes Molekulargewicht: 75 kDa
• GenBank-Zugangsnummer: BC027732
• Gene symbol: GPSM2
• Gene ID (NCBI): 29899
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GPSM2 belongs to a family of proteins that modulate activation of G proteins. GPSM2 assists in the exchange of guanine nucleotides, and allows extracellular signals to be transmitted to cells via cell surface, and ultimately plays a key role in the activation of G-proteins. Therefore, GPSM2 is a critical factor for the stability of cell division. Some recent studies have shown that GPSM2 messenger RNA (mRNA) is overexpressed and plays a positive role in the development of certain tumors, such as liver cancer, pancreatic cancer, breast cancer. It also plays a role in neuroblast division and in the development of normal hearing. Mutations in GPSM2 are associated with autosomal recessive nonsyndromic deafness (DFNB82), which is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss.

Publikationen

Species	Application	Title
mouse	IHC,IF	Am J Hum Genet; Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82.; Authors - Walsh Tom T
mouse	WB	Cell Res; Pins homolog LGN regulates meiotic spindle organization in mouse oocytes.; Authors - Guo Xinzheng X
mouse	IF	Sci Rep; Deletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochlea.; Authors - Yecheng Jin
mouse	WB	Mol Biol Cell; NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.; Authors - Seldin Lindsey L
human	WB	Genes Chromosomes Cancer; Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells.; Authors - Fukukawa Chikako C ; KD Validated
mouse	IF	Mamm Genome; The GPSM2/LGN GoLoco motifs are essential for hearing.; Authors - Yoni Bhonker

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