C1orf112 Polyclonal antibody, PBS Only

• Home
• Products
• Primary Antibodies
• C1orf112 Polyclonal antibody, PBS Only (27863-1-PBS)

• 

  WB analysis using 27863-1-AP (same clone as 27863-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27863-1-AP (C1orf112 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27863-1-PBS in a different storage buffer formulation.

C1orf112 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 27863-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

APOLO1, FIDGETIN-like-1 interacting protein, FIGNL1 Interacting Regulator Of Recombination And Mitosis, FIGNL1-interacting regulator of recombination and mitosis, FIRRM

---

Product Information

27863-1-PBS targets C1orf112 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag27316

  Product name: Recombinant human C1orf112 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 361-530 aa of BC107168

  Sequence: AIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKNKVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEFPWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG

• Full Name: chromosome 1 open reading frame 112
• Calculated Molecular Weight: 853 aa, 97 kDa
• Observed Molecular Weight: 98 kDa
• GenBank Accession Number: BC107168
• Gene Symbol: C1orf112
• Gene ID (NCBI): 55732
• RRID: AB_3742261
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9NSG2
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

FIRRM (Fanconi anemia pathway and RAD51-mediated DNA repair regulator, also known as C1orf112 or FLIP) is an evolutionarily conserved protein involved in DNA damage repair and homologous recombination. It ensures DNA cross-link (ICL) repair and genomic stability by regulating RAD51 activity. FIRRM expression is upregulated in a variety of tumors and correlates with poor prognosis. Its dysfunction leads to increased genomic instability, as evidenced by enhanced DNA damage signaling, chromosomal abnormalities, and micronucleus formation. The study of FIRRM is important for understanding the mechanisms of tumorigenesis and developing new therapeutic strategies.