Product Information
33057-1-PBS targets PTCD1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37639 Product name: Recombinant human PTCD1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 201-595 aa of BC003688 Sequence: VWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAMLHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALIGGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTFCNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYLEKIDGFRAYYKQWLTVMPAEETPHPWQKFRTKPQGDQDTGKEADDGCALGGR Predict reactive species |
| Full Name | pentatricopeptide repeat domain 1 |
| Calculated Molecular Weight | 79 kDa |
| Observed Molecular Weight | 72 kDa |
| GenBank Accession Number | BC003688 |
| Gene Symbol | PTCD1 |
| Gene ID (NCBI) | 26024 |
| RRID | AB_3742841 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | O75127 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
PTCD1 protein (Pentatricopeptide Repeat Domain 1) is a nuclear gene-encoded protein located in the mitochondrial matrix. Its core function lies in regulating mitochondrial gene expression and the assembly of the respiratory chain. It specifically recognizes and binds to mitochondrial RNA (such as mRNA or pre-RNA) through its characteristic pentapeptide repeat sequence (PPR) motif, participating in RNA processing, stability maintenance, or translation processes, thereby being crucial for the assembly and function of mitochondrial oxidative phosphorylation complexes (especially complex I). Its deficiency is associated with mitochondrial dysfunction, neurodegenerative diseases, and cardiomyopathy and other pathological processes.
