PTCD1 Polyclonal antibody

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• PTCD1 Polyclonal antibody (33057-1-AP)

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  WB analysis using 33057-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 33057-1-AP (PTCD1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

PTCD1 Polyclonal Antibody for WB, ELISA

Cat No. 33057-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Synonyms

KIAA0632, Pentatricopeptide repeat-containing protein 1, mitochondrial

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Tested Applications

• Positive WB detected in: Caco-2 cells, MCF-7 cells, MDA-MB-231 cells, mouse testis tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

33057-1-AP targets PTCD1 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag37639

  Product name: Recombinant human PTCD1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 201-595 aa of BC003688

  Sequence: VWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAMLHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALIGGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTFCNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYLEKIDGFRAYYKQWLTVMPAEETPHPWQKFRTKPQGDQDTGKEADDGCALGGR

• Full Name: pentatricopeptide repeat domain 1
• Calculated Molecular Weight: 79 kDa
• Observed Molecular Weight: 72 kDa
• GenBank Accession Number: BC003688
• Gene Symbol: PTCD1
• Gene ID (NCBI): 26024
• RRID: AB_3742841
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: O75127
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PTCD1 protein (Pentatricopeptide Repeat Domain 1) is a nuclear gene-encoded protein located in the mitochondrial matrix. Its core function lies in regulating mitochondrial gene expression and the assembly of the respiratory chain. It specifically recognizes and binds to mitochondrial RNA (such as mRNA or pre-RNA) through its characteristic pentapeptide repeat sequence (PPR) motif, participating in RNA processing, stability maintenance, or translation processes, thereby being crucial for the assembly and function of mitochondrial oxidative phosphorylation complexes (especially complex I). Its deficiency is associated with mitochondrial dysfunction, neurodegenerative diseases, and cardiomyopathy and other pathological processes.