|Positive WB detected in||A549 cells, SH-SY5Y cells, U-87 MG cells, mouse liver tissue|
|Western Blot (WB)||WB : 1:2000-1:10000|
|Sample-dependent, check data in validation data gallery|
13216-1-AP targets SOX5 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||SOX5 fusion protein Ag4092|
|Full Name||SRY (sex determining region Y)-box 5|
|Calculated molecular weight||763 aa, 84 kDa|
|Observed molecular weight||68-70 kDa|
|GenBank accession number||BC029220|
|Gene ID (NCBI)||6660|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Sex determining region Y-box protein 5 (SOX5) is a member of the SOX family, which was identified based on the conserved homology of the high-mobility group DNA-binding motif. It has been reported that SOX5 is involved in the regulation of embryonic development, and is associated with various cancer types, including prostate cancer, glioblastoma, hepatocellular carcinoma, osteosarcoma and nasopharyngeal carcinoma. SOX5 has 5 isoforms with the molecular mass of 42, 71 and 82-84 kDa. (PMID: 30854049)
VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Cell Oncol (Dordr)
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection.
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1.
Mol Cell Biochem
Expression profiles of Sox transcription factors within the postnatal rodent testes.