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Animal-free Recombinant Human IL-7 is expressed in Human 293 cells as a highly glycosylated protein. Under reducing conditions, IL-7 migrates as three separate bands as 19 kDa, 25 kDa and 30 kDa. In comparison IL-7 produced in an E. coli expression system have glycosylation and migrate as a single band at 17 kDa. IL-7 is a hematopoietic cytokine that is important for B and T cell development. When combined with other factors, IL-7 can also co-stimulate the proliferation of mature T cells. Production in human 293 cells uses a serum-free, chemically defined media and offers authentic glycosylation.
Interleukin-7 (IL7) is a cytokine involved in B and T cell development. It plays an active role in the development, survival, maintaining and restoring homeostasis of mature T lymphocytes and is a key regulator of the commitment, survival, proliferation and maturation of B cells during development. Furthermore, IL7 can improve the antiviral function and expansion of natural killer (NK) cells and regulate the development and differentiation of dendritic cells. IL7 has also been reported as a regulator of the development of central nervous system and myogenesis and skeletal muscle cell migration (PMID: 29663382; 29655570; 29449560)