ALDH2 Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 15310-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse lung tissue, human heart tissue, human kidney tissue, human liver tissue, MCF-7 cells, mouse lung tissue, mouse skeletal muscle tissue, rat lung tissue

Positive IP detected in:
mouse lung tissue

Positive IHC detected in:
human liver tissue, human heart tissue, human liver tissue

Positive IF detected in:
A549 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
aldehyde dehydrogenase 2 family (mitochondrial)

Calculated molecular weight:
56 kDa

Observed molecular weight:
50-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ALDH2

Synonyms
ALDH class 2, ALDH E2, ALDH2, ALDHI, ALDM
Background

Acetaldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. It mediates NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol. Thus, the absence of this enzyme is linked to alcohol intolerance and a reduced risk for alcoholism-related liver disease.


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