ATG5 Antibody 28 Publications

Rabbit Polyclonal| Catalog number: 10181-2-AP

Featured Product KD/KO validated

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Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
SH-SY5Y cells,mouse kidney tissue, human brain tissue, Raji cells

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
mouse cortical neurons

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ATG5 autophagy related 5 homolog (S. cerevisiae)

Calculated molecular weight:
32 kDa

Observed molecular weight:
32, 50-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATG5

Synonyms
APG5, APG5 LIKE, APG5L, Apoptosis specific protein, ASP, ATG5, Autophagy protein 5, hAPG5
Background

ATG5, also named as APG5L and ASP, belongs to the ATG5 family. It is required for autophagy. It plays an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. It mediates autophagosome-independent host protection. This antibody is raised against 28-275 amino acids of human ATG5. It can recognize the ATG5-ATG12 complex (55 kDa) and free ATG5 (32 kDa).


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