ATX3,ATXN3 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 13505-1-AP

Featured Product KD/KO validated

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Con: 55 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse pancreas tissue, HEK-293 cells, mouse brain tissue, mouse heart tissue, mouse liver tissue, mouse placenta tissue

Positive IHC detected in:
human pancreas cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ataxin 3

Calculated molecular weight:
370aa,43 kDa

Observed molecular weight:
35-42 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATXN3

Synonyms
AT3, ataxin 3, ATX3, ATXN3, JOS, MJD, MJD1, SCA3
Background

ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one.


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