Brevican Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 19017-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, COLO 320 cells, SH-SY5Y cells, Y79 cells

Positive IHC detected in:
human cerebellum tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
brevican

Calculated molecular weight:
99 kDa

Observed molecular weight:
145 kDa,80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCAN

Synonyms
BCAN, BEHAB, Brevican, Brevican core protein, CSPG7
Background

Brevican is a brain-specific proteoglycan belonging to the aggrecan family that share a number of structural features. Brevican contains a hyaluronic acid-binding domain in its N-terminus and a lectin-like domain in its C-terminus. Expression of brevican is highly specific in the brain and increases as the brain develops. It may play a role in maintaining the extracellular environment of mature brain as a major constituent of the adult brain extracellular matrix (PMID:9117262). Brevican core protein exists as a 145 kDa full-length form and a 80 kDa N terminally truncated form (PMID: 8144512).


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