BEST1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60326-1-Ig |CloneNo.: 4D5F1

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Freight/Packing

Con: 117 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Y79 cells, Transfected HEK-293 cells

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
bestrophin 1

Calculated molecular weight:
585aa,68 kDa

Observed molecular weight:
68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BEST1

Synonyms
ARB, BEST, BEST1, bestrophin 1, BMD, TU15B, VMD2
Background

Bestrophin-1 (BEST1) is a 68 kDa transmembrane protein which belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD).


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