BMI1 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 10832-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
U-937 cells,HEK-293 cells, NCCIT cell, mouse brain tissue, K-562 cells

Positive IP detected in:
U-937 cells

Positive IHC detected in:
human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BMI1 polycomb ring finger oncogene

Calculated molecular weight:
37 kDa

Observed molecular weight:
43-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BMI1

Synonyms
BMI1, PCGF4, Polycomb complex protein BMI 1, RING finger protein 51, RNF51
Background

BMI- 1 is one of polycomb group genes, which together with Ring1 strongly enhances the E3 ubiquitin ligase activity of the Ring2 catalytic subunit. Bmi1 plays an important role in the regulation of cell proliferation and senescence through repression of the p16Ink4a and p19Arf genes and is required for maintenance of adult hematopoietic and neural stem cells The antibody 10832-1-AP detected proteins of 45-48kda, which may include phosphorylated isoforms of the protein.


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