BMP7 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 12221-1-AP

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Freight/Packing

Con: 27 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, MCF-7 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human renal cell carcinoma tissue, human bladder tissue, human kidney tissue, human renal cell carcinoma tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
bone morphogenetic protein 7

Calculated molecular weight:
431aa,49 kDa

Observed molecular weight:
49 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BMP7

Synonyms
BMP 7, BMP7, bone morphogenetic protein 7, Eptotermin alfa, OP 1, OP1, Osteogenic protein 1
Background

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.

BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).


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