BST2 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 13560-1-AP

Featured Product KD/KO validated

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Con: 75 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human heart tissue, human heart tissue, human liver tissue, L02 cells

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
bone marrow stromal cell antigen 2

Calculated molecular weight:
180aa,20 kDa

Observed molecular weight:
30-36 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BST2

Synonyms
Bone marrow stromal antigen 2, BST 2, BST2, CD317, HM1.24 antigen, Tetherin
Background

BST2, also named as CD317 and Tetherin, belongs to the tetherin family. It may be involved in the sorting of secreted proteins and it is involved in pre-B-cell growth. BST2 is an antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. BST2 may play a role in B-cell activation in rheumatoid arthritis. It is recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. BST2 is a plasma membrane proteins, tetherin inhibits virion particle release from infected cells. BST2 is effective against retroviruses and flavoviruses whilst IFITMs disrupt influenza and flavivirus infection.


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