Bestrophin-1 Polyclonal antibody

Bestrophin-1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG







Cat no : 55012-1-AP


ARB, BEST, BEST1, bestrophin 1, Bestrophin-1, BMD, TU15B, VMD2

Tested Applications

Recommended dilution

Sample-dependent, check data in validation data gallery

Product Information

55012-1-AP targets Bestrophin-1 in ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name bestrophin 1
Calculated molecular weight 69 kDa
GenBank accession numberNM_004183
Gene symbol BEST1
Gene ID (NCBI) 7439
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer 0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Aliquoting is unnecessary for -20oC storage.

Background Information

Bestrophin-1 (BEST1) is a 68 kDa transmembrane protein which belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD).