C3 / C3b / C3c Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 21337-1-AP

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Freight/Packing

Con: 24 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human blood tissue

Positive IP detected in:
human plasma tissue

Positive IHC detected in:
human liver tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
complement component 3

Calculated molecular weight:
1663aa,187 kDa

Observed molecular weight:
115 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
C3

Synonyms
ARMD9, ASP, C3, C3b, C3c, Complement C3, complement component 3, CPAMD1
Background

The complement system is an important effector which bridges the innate and adaptive immune systems (PMID: 20010915). The third component of complement, C3, plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways (PMID: 11414361). Human C3, composed of α and β chains (115 and 75 kDa, respectively), is cleaved into C3a and C3b by C3 convertase. C3b is further cleaved into iC3b, C3c, C3dg and C3f. This antibody raised against 1314-1663 aa of human C3 protein recognize C3 alpha chain, C3b alpha' chain, and C3c alpha' chain fragment 2.


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