Cyclin T1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 20992-1-AP

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Freight/Packing

Con: 57 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, A431 cells, HeLa cells, Jurkat cells, K-562 cells, Y79 cells

Recommended dilution:
WB : 1:200-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
cyclin T1

Calculated molecular weight:
81 kDa

Observed molecular weight:
87 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CCNT1

Synonyms
CCNT, CCNT1, Cyclin T, cyclin T1, CYCT1, HIVE1
Background

CCNT1, also named as CycT1, belongs to the cyclin family and Cyclin C subfamily. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex which also called positive transcription elongation factor B (P-TEFb). In case of HIV or SIV infections, CCNT1 binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). CCNT1 serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. The antibody is specific to CCNT1.


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