CD100 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 14422-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 20 μg/150 μl

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Tested Applications

Applications:
WB, IHC, ELISA
Application not tested? Please see our Guarantee




Species specificity:
human, mouse

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Calculated molecular weight:
96 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SEMA4D

Synonyms
A8, BB18, C9orf164, CD100, coll 4, GR3, M sema G, SEMA4D, SEMAJ, Semaphorin 4D
Background

CD100 (also known as SEMA4D), a 150 kDa homodimer, belongs to the family of immune semaphorins, and CD100 is abundantly expressed on resting T cells, NK cells, and antigen-presenting cells. As a transmembrane glycoprotein, it is digested to its soluble form, sCD100, by specific matrix metalloproteinases. CD100 has been reported that the expression levels of CD100, and one of its receptors, plexin-B1 (PLXNB1), are increased in head and neck, prostate, colon, breast, and lung cancers, and the interaction between them provides oncogenic signaling essential for tumor growth and metastasis.


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