CXCL8,IL8 Antibody 4 Publications

Mouse Monoclonal| Catalog number: 60141-1-Ig |CloneNo.: 3C4E2

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Freight/Packing

Con: 75 μg/150 μl

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Species specificity:
human

Recommended dilution:

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interleukin 8

Calculated molecular weight:
99aa,11 kDa

Observed molecular weight:
11kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IL8

Synonyms
IL8, Protein 3 10C, IL 8(1 77), (Ala IL 8)77, LYNAP
Background

Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.


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