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CXCR1, also named as CMKAR1, IL8RA and CD181, belongs to the G-protein coupled receptor 1 family. It is a receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. CXCR1binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. This antibody is specific to CXCR1.